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Apatite Microtopographies Instruct Signaling Tapestries for Progenitor-Driven New Attachment of Teeth

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Title: Apatite Microtopographies Instruct Signaling Tapestries for Progenitor-Driven New Attachment of Teeth
Author(s): Dangaria, Smit J.; Ito, Yoshihiro; Yin, LeiLei; Valdre, Giovanni; Luan, Xianghong; Diekwisch, Thomas G.H.
Subject(s): human periodontal ligament extracellular matrix gingival fibroblasts nanoscale topography
Abstract: Dimension and structure of extracellular matrix surfaces have powerful influences on cell shape, adhesion, and gene expression. Here we show that natural tooth root topographies induce integrin-mediated extracellular matrix signaling cascades in tandem with cell elongation and polarization to generate physiological periodontium-like tissues. In this study we replanted surface topography instructed periodontal progenitors into rat alveolar bone sockets for 8 and 16 weeks, resulting in complete reattachment of tooth roots to the surrounding alveolar bone with a periodontal fiber apparatus closely matching physiological controls along the entire root surface. Displacement studies and biochemical analyses confirmed that progenitor-based engineered periodontal tissues were similar to control teeth and uniquely derived from preimplantation green fluorescent protein (GFP)-labeled progenitors. Together, these studies illustrate the capacity of natural extracellular surface topographies to instruct progenitor cell populations to fully regenerate complex cellular and structural morphologies of tissues once lost to disease. We suggest that our strategy could be used for the replantation of teeth lost due to trauma or as a novel approach for tooth replacement using tooth-shaped replicas.
Issue Date: 2011-02
Publisher: Mary Ann Liebert
Citation Info: Dangaria, S. J., Ito, Y., Yin, L., Valdre, G., Luan, X., & Diekwisch, T. G. 2011. Apatite microtopographies instruct signaling tapestries for progenitor-driven new attachment of teeth. Tissue Eng Part A., 17(3-4): 279-290. DOI: 10.1089/ten.tea.2010.0264
Type: Article
Description: This is a copy of an article published in Tissue Engineering Part A © 2011 Copyright Mary Ann Liebert, Inc.; Tissue Engineering Part A is available online at: (DOI: 10.1089/ten.tea.2010.0264)
ISSN: 1937-3341
Sponsor: Studies were generously supported by the National Institutes of Health Grant DE15045 to T.G.H.D.
Date Available in INDIGO: 2011-05-27

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