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Barbarians at the Gate

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Title: Barbarians at the Gate
Author(s): Barry, Sheila
Abstract: My research examines the roles of different cells mediating sexual transmission of HIV in male genital tissue. Due to their proximity to the tissue surface, I am particularly interested in Langerhans cells (LCs), an antigen-presenting cell concentrated in mucosal tissues. I have shown previously that in vitro derived LCs are capable of enhancing HIV infection of target cells following activation. Recent publications have suggested male circumcision may provide some protection against acquiring HIV infection. Since LCs exist in high concentrations within male foreskin, I am therefore investigating their involvement in mediating HIV transmission in this tissue. The image displays Langerhans cells within male foreskin. Tissue samples were sectioned to 10µm thickness, then stained with antibodies against LC-specific cell surface markers. Images were acquired on a microscope equipped with deconvolution software. LCs are seen in green, with tissue structure visible in orange. Cell nuclei are stained blue. Using this image, and several other similar images, I have been to examine the localization of LCs in tissue.
Issue Date: 2008
Type: Image
Description: Honorable mention in The Image of Research, a competition for students in graduate or professional degree programs at UIC, sponsored by UIC's Graduate College and the University Library. Images of award recipients and finalists on exhibition in the Richard J. Daley Library and the Library of the Health Sciences, May 2-30, 2008. Honorable mention images on exhibition in Richard J. Daley Library, May 2-30, 2008.
Date Available in INDIGO: 2008-05-21

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