INDIGO Home University of Illinois at Urbana-Champaign logo uic building uic pavilion uic student center

Abnormal 8-Hz flicker electroretinograms in carriers of X-linked retinoschisis.

Show full item record

Bookmark or cite this item:

Files in this item

File Description Format
PDF Abnormal 8 Hz flicker.pdf (653KB) Manuscript PDF
Title: Abnormal 8-Hz flicker electroretinograms in carriers of X-linked retinoschisis.
Author(s): McAnany JJ; Park JC; Collison FT; Fishman GA; Stone EM
Subject(s): Cone Electroretinogram (ERG) Flicker Rod X-linked retinoschisis
Abstract: PURPOSE: To evaluate rod-isolated, cone-isolated, and combined rod and cone flicker electroretinograms (ERGs) as a possible means to identify electrophysiological abnormalities in carriers of X-linked retinoschisis (XLRS). METHODS: Full-field ERGs were recorded from six carriers of XLRS (aged 34-66 years) and eight normally sighted subjects (aged 27-59 years) under rod-isolated (ERGR), cone-isolated (ERGC), and combined rod and cone (ERGR+C) conditions. ERGs were obtained using a four-primary LED-based ganzfeld photostimulator and standard recording techniques. The four primaries were modulated sinusoidally in phase to achieve combined rod and cone activation (ERGR+C) or in different phases to achieve ERGR and ERGC by means of triple silent substitution. After 30 min of dark adaptation, 8- and 15-Hz ERGR, ERGC, and ERGR+C responses were obtained at a mean luminance level of 24 scot. cd/m(2). Standard ISCEV ERGs were also obtained from each subject. RESULTS: The ISCEV and 15-Hz flicker ERGs were generally within the normal range for the carriers. The 8-Hz ERGR, ERGC, and ERGR+C amplitudes were also generally normal. In contrast, the carriers had ERGR, ERGC, and ERGR+C timing abnormalities, with phase advances beyond the range of normal for the ERGR (four carriers), ERGC (four carriers), and ERGR+C (three carriers). Only one carrier had normal 8-Hz responses under all conditions. CONCLUSIONS: The 8-Hz ERG timing abnormalities in five of six carriers indicate that retinal function is not necessarily normal in carriers of XLRS. The 8-Hz flicker ERG may be useful for studying retinal function in these individuals.
Issue Date: 2016-08-01
Publisher: Springer Verlag
Citation Info: McAnany, J. J., Park, J. C., Collison, F. T., Fishman, G. A. and Stone, E. M. Abnormal 8-Hz flicker electroretinograms in carriers of X-linked retinoschisis. Documenta Ophthalmologica. 2016. 133(1): 61-70.DOI: 10.1007/s10633-016-9551-0.
Type: Article
Description: This is the author’s version of a work that was accepted for publication in Documenta Ophthalmologica. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Documenta Ophthalmologica. 2016. 133(1): 61-70. DOI: 10.1007/s10633-016-9551-0.
ISSN: 0012-4486
Sponsor: This research was supported by National Institutes of Health Research Grants R00EY019510 (JM), P30EY001792 (UIC core Grant), an unrestricted departmental Grant from Research to Prevent Blindness, the Pangere Family Foundation, and the Grousbeck Family Foundation (GAF and EMS).
Date Available in INDIGO: 2017-09-09

This item appears in the following Collection(s)

Show full item record


Country Code Views
United States of America 58
China 46
Russian Federation 16
Ukraine 15
Germany 3


My Account


Access Key