INDIGO Home University of Illinois at Urbana-Champaign logo uic building uic pavilion uic student center

Stem cell transplantation of matched sibling donors compared with immunosuppressive therapy for acquired severe aplastic anaemia: a Cochrane systematic review

Show full item record

Bookmark or cite this item: http://hdl.handle.net/10027/21164

Files in this item

File Description Format
PDF Stem Cell trans ... matched sibling donors.pdf (1MB) (no description provided) PDF
Title: Stem cell transplantation of matched sibling donors compared with immunosuppressive therapy for acquired severe aplastic anaemia: a Cochrane systematic review
Author(s): Peinemann, Frank; Labeit, Alexander M.
Abstract: Objectives: Acquired severe aplastic anaemia is a rare and potentially fatal disease. The aim of this Cochrane review was to evaluate the effectiveness and adverse events of first-line allogeneic haematopoietic stem cell transplantation of human leucocyte antigen (HLA)-matched sibling donors compared with first-line immunosuppressive therapy. Setting: Specialised stem cell transplantations units in primary care hospitals. Participants: We included 302 participants with newly diagnosed acquired severe aplastic anaemia. The age ranged from early childhood to young adulthood. We excluded studies on participants with secondary aplastic anaemia. Interventions: We included allogeneic haematopoietic stem cell transplantation as the test intervention harvested from any source of matched sibling donor and serving as a first-line therapy. We included immunosuppressive therapy as comparator with either antithymocyte/antilymphocyte globulin or ciclosporin or a combination of the two. Primary and secondary outcome measures planned and finally measured: The primary outcome was overall mortality. Secondary outcomes were treatment-related mortality, graft failure, graft-versus-host disease, no response to immunosuppressive therapy, relapse after initial successful treatment, secondary clonal disease or malignancies, health-related quality of life and performance scores. Results: We identified three prospective non-randomised controlled trials with a study design that was consistent with the principle of 'Mendelian randomisation' in allocating patients to treatment groups. All studies had a high risk of bias due to the study design and were conducted more than 15 years. The pooled HR for overall mortality for the donor group versus the no donor group was 0.95 (95% CI 0.43 to 2.12, p=0.90). Conclusions: There are insufficient and biased data that do not allow any firm conclusions to be made about the comparative effectiveness of first-line allogeneic haematopoietic stem cell transplantation of HLA-matched sibling donors and first-line immunosuppressive therapy of patients with acquired severe aplastic anaemia.
Issue Date: 2014-07-15
Publisher: BMJ Publishing Group
Citation Info: Peinemann, Frank, and Alexander Michael Labeit. "Stem cell transplantation of matched sibling donors compared with immunosuppressive therapy for acquired severe aplastic anaemia: a Cochrane systematic review." BMJ open 4, no. 7 (2014): e005039. DOI: 10.1136/bmjopen-2014-005039
Type: Article
Description: This is a copy of an article published in the BMJ Open. © Peinemann F, et al. http://bmjopen.bmj.com/
URI: http://hdl.handle.net/10027/21164
ISSN: 2044-6055
Sponsor: Provision of full texts by the University of Cologne, Germany. The publication of this article was supported by the University of Illinois at Chicago (UIC) Research Open Access Article Publishing (ROAAP) Fund.
Date Available in INDIGO: 2016-09-14
 

This item appears in the following Collection(s)

Show full item record

Statistics

Country Code Views
United States of America 71
China 20
Russian Federation 19
United Kingdom 7
Ukraine 5

Browse

My Account

Information

Access Key