INDIGO Home University of Illinois at Urbana-Champaign logo uic building uic pavilion uic student center

Spontaneous complete remission of type 1 diabetes mellitus in an adult- Review and case report

Show full item record

Bookmark or cite this item:

Files in this item

File Description Format
PDF Spontaneous com ... s mellitus in an adult.pdf (344KB) (no description provided) PDF
Title: Spontaneous complete remission of type 1 diabetes mellitus in an adult- Review and case report
Author(s): Moole, Harsha; Moole, Vishnu; Mamidipalli, Adrija; Dharmapuri, Sowmya; Boddireddy, Raghuveer; Taneja, Deepak; Sfeir, Hady; Gajula, Sonia
Subject(s): Type 1 diabetes mellitus honeymoon period spontaneous complete remission partial remission
Abstract: Type 1 diabetes mellitus (T1DM) is an autoimmune condition that results in low plasma insulin levels by destruction of beta cells of the pancreas. As part of the natural progression of this disease, some patients regain beta cell activity transiently. This period is often referred to as the ‘honeymoon period’ or remission of T1DM. During this period, patients manifest improved glycemic control with reduced or no use of insulin or anti-diabetic medications. The incidence rates of remission and duration of remission is extremely variable. Various factors seem to influence the remission rates and duration. These include but are not limited to C-peptide level, serum bicarbonate level at the time of diagnosis, duration of T1DM symptoms, haemoglobin A1C (HbA1C) levels at the time of diagnosis, sex, and age of the patient. Mechanism of remission is not clearly understood. Extensive research is ongoing in regard to the possible prevention and reversal of T1DM. However, most of the studies that showed positive results were small and uncontrolled. We present a 32-yearold newly diagnosed T1DM patient who presented with diabetic ketoacidosis (DKA) and HbA1C of 12.7%. She was on basal bolus insulin regimen for the first 4 months after diagnosis. Later, she stopped taking insulin and other anti-diabetic medications due to compliance and logistical issues. Eleven months after diagnosis, her HbA1C spontaneously improved to 5.6%. Currently (14 months after T1DM diagnosis), she is still in complete remission, not requiring insulin therapy.
Issue Date: 2015-10-19
Publisher: Co-Action Publishing
Citation Info: Moole, Harsha, Vishnu Moole, Adrija Mamidipalli, Sowmya Dharmapuri, Raghuveer Boddireddy, Deepak Taneja, Hady Sfeir, and Sonia Gajula. "Spontaneous complete remission of type 1 diabetes mellitus in an adult–review and case report." Journal of community hospital internal medicine perspectives 5, no. 5 (2015). DOI: 10.3402/jchimp.v5.28709
Type: Article
Description: This is a copy of an article published in the Journal of community hospital internal medicine perspectives. © 2015 Harsha Moole et al.
ISSN: ESSN: 2000-9666
Sponsor: The Research Open Access Article Publishing (ROAAP) Fund of the University of Illinois at Chicago for financial support towards the open access publishing fee for this article.
Date Available in INDIGO: 2016-09-12

This item appears in the following Collection(s)

Show full item record


Country Code Views
China 175
United States of America 78
Russian Federation 24
Ukraine 7
Germany 3


My Account


Access Key