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Autophagy and apoptosis in liver injury

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Title: Autophagy and apoptosis in liver injury
Author(s): Wang, Kewei
Subject(s): autophagy apoptosis liver injury cross-talk mechanism
Abstract: Apoptosis is a primary characteristic in the pathogenesis of liver disease. Hepatic apoptosis is regulated by autophagic activity. However, mechanisms mediating their interaction remain to be determined. Basal level of autophagy ensures the physiological turnover of old and damaged organelles. Autophagy also is an adaptive response under stressful conditions. Autophagy can control cell fate through different cross-talk signals. A complex interplay between hepatic autophagy and apoptosis determines the degree of hepatic apoptosis and the progression of liver disease as demonstrated by pre-clinical models and clinical trials. This review summarizes recent advances on roles of autophagy that plays in pathophysiology of liver. The autophagic pathway can be a novel therapeutic target for liver disease.
Issue Date: 2015-01-01
Publisher: Taylor and Francis
Citation Info: Wang, Kewei. "Autophagy and apoptosis in liver injury." Cell Cycle 14, no. 11 (2015): 1631-1642. DOI: 10.1080/15384101.2015.1038685
Type: Article
Description: This is an electronic version of an article published in Wang, Kewei. "Autophagy and apoptosis in liver injury." Cell Cycle 14, no. 11 (2015): 1631-1642. Cell Cycle is available online at: http://dx.doi.org/10.1080/15384101.2015.1038685. http://www.informaworld.com/smpp/ DOI:10.1080/15384101.2015.1038685
URI: http://hdl.handle.net/10027/21094
ISSN: 1538-4101
Date Available in INDIGO: 2016-08-29
 

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