INDIGO Home University of Illinois at Urbana-Champaign logo uic building uic pavilion uic student center

PLGA-Curcumin Attenuates Opioid-Induced Hyperalgesia and Inhibits Spinal CaMKIIα.

Show simple item record

Bookmark or cite this item: http://hdl.handle.net/10027/21035

Files in this item

File Description Format
PDF PLGA-Curcumin.pdf (2MB) Main Article PDF
Title: PLGA-Curcumin Attenuates Opioid-Induced Hyperalgesia and Inhibits Spinal CaMKIIα.
Author(s): Hu, X; Huang, F; Szymusiak, M; Tian, X; Liu, Y; Wang, ZJ
Abstract: Opioid-induced hyperalgesia (OIH) is one of the major problems associated with prolonged use of opioids for the treatment of chronic pain. Effective treatment for OIH is lacking. In this study, we examined the efficacy and preliminary mechanism of curcumin in attenuating OIH. We employed a newly developed PLGA-curcumin nanoformulation (PLGA-curcumin) in order to improve the solubility of curcumin, which has been a major obstacle in properly characterizing curcumin's mechanism of action and efficacy. We found that curcumin administered intrathecally or orally significantly attenuated hyperalgesia in mice with morphine-induced OIH. Furthermore, we demonstrated that the effects of curcumin on OIH correlated with the suppression of chronic morphine-induced CaMKIIα activation in the superficial laminae of the spinal dorsal horn. These data suggest that PLGA-curcumin may reverse OIH possibly by inhibiting CaMKIIα and its downstream signaling.
Issue Date: 2016-01-08
Publisher: Public Library of Science
Citation Info: Hu, X. Y., Huang, F., Szymusiak, M., Tian, X. B., Liu, Y. and Wang, Z. J. PLGA-Curcumin Attenuates Opioid-Induced Hyperalgesia and Inhibits Spinal CaMKII alpha. PLoS One. 2016. 11(1). DOI: 10.1371/journal.pone.0146393.
Type: Article
Description: This is a copy of an article published in PLoS ONE. © 2016 Public Library of Science Publications. © 2016 Hu et al.
URI: http://hdl.handle.net/10027/21035
ISSN: 1932-6203
Sponsor: This work was supported in part by a grant (K07 AT003647) from the National Center for Complementary and Alternative Medicine (NCCAM), National Institutes of Health (NIH http://www.nih.gov). Nanoparticle formation and characterization were supported by NSF Career Award (NSF-CMMI 1350731 http://www.nsf.gov). Mechanistic CaMKII study received funds from NSFc (81328009).
Date Available in INDIGO: 2016-08-08
 

This item appears in the following Collection(s)

Show simple item record

Statistics

Country Code Views
United States of America 102
China 49
Russian Federation 16
Germany 6
Italy 2

Browse

My Account

Information

Access Key