INDIGO Home University of Illinois at Urbana-Champaign logo uic building uic pavilion uic student center

International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: Proposed Diagnostic Criteria for Chronic GVHD (Part I)

Show full item record

Bookmark or cite this item: http://hdl.handle.net/10027/20347

Files in this item

File Description Format
PDF srep03419.pdf (573KB) (no description provided) PDF
Title: International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: Proposed Diagnostic Criteria for Chronic GVHD (Part I)
Author(s): Ogawa, Yoko; Kim, Stella K.; Dana, Reza; Clayton, Janine; Jain, Sandeep; Rosenblatt, Mark I.; Perez, Victor L.; Shikari, Hasanain; Riemens, Anjo; Tsubota, Kazuo
Subject(s): Eye manifestations, Biomarker research Diagnostic markers, Haematological diseases
Abstract: The International Chronic Ocular GVHD Consensus Group held 4 working meetings to define new diagnostic metrics for chronic ocular graft-versus-host disease (GVHD). After considering the factors currently used to diagnose chronic ocular GVHD, the Consensus Group identified 4 subjective and objective variables to measure in patients following allogeneic hematopoietic stem cell transplantation (HSCT): OSDI, Schirmer's score without anesthesia, corneal staining, and conjunctival injection. Each variable was scored 0–2 or 0–3, with a maximum composite score of 11. Consideration was also given to the presence or the absence of systemic GVHD. On the basis of their composite score and the presence or absence of systemic GVHD, patients were assigned to one of three diagnostic categories: NO, PROBABLE, or DEFINITE ocular GVHD. New diagnostic criteria for chronic ocular GVHD are presented by the Consensus Group. Validation studies are needed to identify the best combination of the proposed metrics to maximize diagnostic sensitivity and specificity.
Issue Date: 2013
Publisher: Nature Publishing Group
Citation Info: Ogawa, Y., Kim, S. K., Dana, R., Clayton, J., Jain, S., Rosenblatt, M. I., Perez, V. L., Shikari, H., Riemens, A. and Tsubota, K. International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: Proposed Diagnostic Criteria for Chronic GVHD (Part I). SCIENTIFIC REPORTS. 2013. 3. doi: 10.1038/srep03419.
Type: Article
URI: http://hdl.handle.net/10027/20347
ISSN: 2045-2322
Sponsor: This work was supported by the grant for Global Clinical Research Center Program for Keio University from Japanese Ministry of Health, Labor, and Welfare 2011.
Date Available in INDIGO: 2016-04-01
 

This item appears in the following Collection(s)

Show full item record

Statistics

Country Code Views
China 141
United States of America 123
Russian Federation 12
Ukraine 9
Germany 6

Browse

My Account

Information

Access Key