INDIGO Home University of Illinois at Urbana-Champaign logo uic building uic pavilion uic student center

Basal Autophagy Is Required for Herpes simplex Virus-2 Infection.

Show full item record

Bookmark or cite this item: http://hdl.handle.net/10027/20049

Files in this item

File Description Format
PDF Basal Autophagy.pdf (2MB) Main article PDF
Title: Basal Autophagy Is Required for Herpes simplex Virus-2 Infection.
Author(s): Yakoub, AM; Shukla, D.
Abstract: Autophagy is a conserved catabolic process of the cell, which plays an important role in regulating plethora of infections. The role of autophagy in Herpes simplex virus-2 (HSV-2) infection is unknown. Here, we found that HSV-2 does not allow induction of an autophagic response to infection, but maintains basal autophagy levels mostly unchanged during productive infection. Thus, we investigated the importance of basal autophagy for HSV-2 infection, using pharmacological autophagy suppression or cells genetically deficient in an autophagy-essential gene (ATG5). Interference with basal autophagy flux in cells significantly reduced viral replication and diminished the infection. These results indicate that basal autophagy plays an indispensable role required for a productive infection. Importantly, this study draws a sharp distinction between induced and basal autophagy, where the former acts as a viral clearance mechanism abrogating infection, while the latter supports infection.
Issue Date: 2015-08-07
Publisher: Nature Publishing Group
Citation Info: Yakoub, A. M. and Shukla, D. Basal Autophagy Is Required for Herpes simplex Virus-2 Infection. Scientific Reports. 2015. 5. DOI: 10.1038/srep12985.
Type: Article
Description: This is the copy of an article published in Scientific Reports © 2015 Nature Publishing Group Publications. © The Author(s).
URI: http://hdl.handle.net/10027/20049
ISSN: 2045-2322
Sponsor: This study was supported by a NIH grant (EY023058) to D.S. and a core grant (EY01792). The authors claim no conflicts of interest.
Date Available in INDIGO: 2016-01-27
 

This item appears in the following Collection(s)

Show full item record

Statistics

Country Code Views
United States of America 105
China 78
Ukraine 18
Germany 10
Russian Federation 10

Browse

My Account

Information

Access Key