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Natural Products with Biological Activities from Freshwater Cyanobacteria

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Title: Natural Products with Biological Activities from Freshwater Cyanobacteria
Author(s): Luo, Shangwen
Advisor(s): Orjala, Jimmy
Contributor(s): Swanson, Steven M.; Murphy, Brian T.; Che, Chun-Tao; Johnson, Jeremy J.
Department / Program: Medicinal Chemistry and Pharmacognosy
Graduate Major: Pharmacognosy
Degree Granting Institution: University of Illinois at Chicago
Degree: PhD, Doctor of Philosophy
Genre: Doctoral
Subject(s): Cyanobacteria Lipopeptide Cyclophane Natural Products Secondary Metabolites
Abstract: In this study, bioassay-guided fractionation was utilized to find novel secondary metabolites from cultured and field collected freshwater cyanobacteria. The structures of these new compounds were elucidated using HRESIMS, 1D/2D NMR, QTOF MS/MS, CD spectroscopy, chemical synthesis, and advanced Marfey’s analysis. These new secondary metabolites were evaluated for their antiproliferative, antimicrobial, antifungal and protease inhibiting activities.
Issue Date: 2015-07-21
Genre: thesis
Rights Information: Copyright 2015 Shangwen Luo
Date Available in INDIGO: 2017-07-22
Date Deposited: 2015-05

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