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Synthesis and Evaluation of Oligospermines for Nucleic Acid Delivery

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Title: Synthesis and Evaluation of Oligospermines for Nucleic Acid Delivery
Author(s): Lote, Asawari R.
Advisor(s): Kolhatkar, Rohit B.
Contributor(s): Hong, Seungpyo; He, Xiaolong
Department / Program: Biopharmaceutical Sciences
Graduate Major: Biopharmaceutical Sciences
Degree Granting Institution: University of Illinois at Chicago
Degree: MS, Master of Science
Genre: Masters
Subject(s): Spermine Oligospermines Nucleic Acid Delivery
Abstract: A variety of delivery vehicles use spermine as a polycationic component to form complexes with nucleic acids. Thus, we investigated the influence of molecular architecture, amine density, and molecular weight of oligospermines on its binding to nucleic acids. We report the synthesis of cyclic, aminocyclic and quatrefoil architecture and evaluated their efficiency to bind to nucleic acid with other linear and dendritic oligospermines synthesized in our laboratory. The effect of molecular weight was more pronounced in linear oligospermines than their cyclic counterparts. Oligospermines with similar amine density but different molecular architecture exhibited different binding profiles. Among all oligospermines evaluated, dendritic tetraspermine exhibited the highest binding affinity. Importantly, dendritic tetraspermine was less toxic than linear tetraspermine, suggesting its potential in nucleic acid delivery.
Issue Date: 2015-07-21
Genre: thesis
URI: http://hdl.handle.net/10027/19578
Rights Information: Copyright 2015 Asawari R. Lote
Date Available in INDIGO: 2017-07-22
Date Deposited: 2015-05
 

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