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Curcumin in VIP-Targeted Sterically Stabilized Phospholipid Nanomicelles: A Novel Therapeutic Approach for Breast Cancer and Breast Cancer Stem Cells

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Title: Curcumin in VIP-Targeted Sterically Stabilized Phospholipid Nanomicelles: A Novel Therapeutic Approach for Breast Cancer and Breast Cancer Stem Cells
Author(s): Gülçür, Ece; Thaqi, Mentor; Khaja, Fatima; Kuzmis, Antonina; Önyüksel, Hayat
Subject(s): Curcumin sterically stabilized phospholipid micelles nanoparticles breast cancer stem cells targeted drug delivery vasoactive intestinal peptide
Abstract: Breast cancer is a leading cause of cancer deaths among women in the US, with 40 % chance of relapse after treatment. Recent studies outline the role of cancer stem cells (CSCs) in tumor initiation, propagation, and regeneration of cancer. Moreover, it has been established that breast CSCs reside in a quiescent state that makes them more resistant to conventional cancer therapies than bulk cancer cells resulting in tumor relapse. In this study, we establish that CSCs are associated with the overexpression of vasoactive intestinal peptide (VIP) receptors which can be used to actively target these cells. We investigated the potential of using a novel curcumin nanomedicine (C-SSM) surface conjugated with VIP to target and hinder breast cancer with CSCs. Here, we formulated, characterized, and evaluated the feasibility of C-SSM nanomedicine in vitro. We investigated the cytotoxicity of C-SSM on breast cancer cells and CSCs by tumorsphere formation assay. Our results suggest that curcumin can be encapsulated in SSM up to 200 mug/ml with 1 mM lipid concentration. C-SSM nanomedicine is easy to prepare and maintains its original physicochemical properties after lyophilization, with an IC50 that is significantly improved from that of free curcumin (14.2+/-1.2 vs. 26.1+/-3.0 muM). Furthermore, C-SSM-VIP resulted in up to 20 % inhibition of tumorsphere formation at a dose of 5 muM. To this end, our findings demonstrate the feasibility of employing our actively targeted nanomedicine as a potential therapy for CSCs-enriched breast cancer.
Issue Date: 2013-12-24
Publisher: Drug Delivery and Translational Research
Citation Info: Gulcur, E., Thaqi, M., Khaja, F., Kuzmis, A. and Onyuksel, H. Curcumin in VIP-targeted sterically stabilized phospholipid nanomicelles: a novel therapeutic approach for breast cancer and breast cancer stem cells. Drug Delivery and Translational Research. 2013. 3(6).
Type: Article
URI: http://hdl.handle.net/10027/18946
ISSN: 2190-393X
Date Available in INDIGO: 2014-11-10
 

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