INDIGO Home University of Illinois at Urbana-Champaign logo uic building uic pavilion uic student center

A 20-year multi-follow-up of hallucinations in schizophrenia, other psychotic, and mood disorders

Show full item record

Bookmark or cite this item: http://hdl.handle.net/10027/12840

Files in this item

File Description Format
PDF Pages from S0033291712002206a.pdf (147KB) Main Article PDF
Title: A 20-year multi-follow-up of hallucinations in schizophrenia, other psychotic, and mood disorders
Author(s): Goghari, V. M.; Harrow, M.; Grossman, L. S.; Rosen, C.
Subject(s): Bipolar disorder depression psychosis disease course schizoaffective
Abstract: Background. Hallucinations are a major aspect of psychosis and a diagnostic feature of both psychotic and mood disorders. However, the field lacks information regarding the long-term course of hallucinations in these disorders. Our goals were to determine the percentage of patients with hallucinations and the relationship between hallucinations and recovery, and work attainment. Method. The present study was a prospective evaluation of the 20-year trajectory of hallucinations in 150 young patients : 51 schizophrenia, 25 schizoaffective, 25 bipolar with psychosis, and 49 unipolar depression. The patients were studied at an index phase of hospitalization for hallucinations, and then reassessed longitudinally at six subsequent follow-ups over 20 years. Results. The longitudinal course of hallucinations clearly differentiated between schizophrenia and bipolar disorder with psychosis, and suggested some diagnostic similarities between schizophrenia and schizoaffective disorder, and between bipolar disorder and schizoaffective disorder and depression. Frequent or persistent hallucinatory activity over the 20-year period was a feature of 40-45% of schizophrenia patients. The early presence of hallucinations predicted the lack of future periods of recovery in all patients. Increased hallucinatory activity was associated with reduced work attainment in all patients. Conclusions. This study provides data on the prospective longitudinal course of hallucinations, which were previously unavailable to the field, and are one of the key features of psychosis in major psychiatric disorders. This information on the clinical course of major psychiatric disorders can inform accurate classification and diagnosis.
Issue Date: 2013-06
Publisher: Cambridge University Press
Citation Info: Goghari, V. M., Harrow, M., Grossman, L. S. and Rosen, C. A 20-year multi-follow-up of hallucinations in schizophrenia, other psychotic, and mood disorders. Psychological Medicine. 2013. 43(6): 1151-1160. DOI: 10.1017/S0033291712002206
Type: Article
Description: This is a copy of an article published in the Psychological Medicine © 2013 Cambridge University Press. Available at http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8905946
URI: http://hdl.handle.net/10027/12840
ISSN: 0033-2917
Sponsor: Funding was provided by the National Institute of Mental Health (NIMH) (grants no. MH-26341 and no. MH-068688 to M.H.). V.M.G. was funded by a Canadian Institutes of Health Research New Investigator Award and a University of Calgary Start-up Grant.
Date Available in INDIGO: 2014-06-25
 

This item appears in the following Collection(s)

Show full item record

Statistics

Country Code Views
United States of America 355
China 108
Russian Federation 32
Germany 23
Japan 10

Browse

My Account

Information

Access Key