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Dendritic Nanoparticles: The next generation of nanocarriers?

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Title: Dendritic Nanoparticles: The next generation of nanocarriers?
Author(s): Pearson, Ryan M.; Sunoqrot, Suhair; Hsu, Hao-jui; Bae, Jin Woo; Hong, Seungpyo
Subject(s): Dendrimers Nanoparticles Dendron micelles Nanotechnology drug delivery Multivalent Binding nanocarrier polymer
Abstract: Dendritic polymers have attracted a great deal of scientific interests due to their well-defined unique structure and capability to be multifunctionalized. Here we present a comprehensive overview of various dendrimer-based nanoparticles that are currently being investigated for drug delivery and diagnostics applications. Through a critical review of the old and new dendritic designs, we highlight the advantages and disadvantages of these systems and their structure- biological property relationships. This paper also focuses on the major challenges facing the clinical translation of these nanodevices, and how these challenges are being (or should be) addressed, which will greatly benefit the overall progress of dendrimer-based technologies for theranostics.
Issue Date: 2012-08
Publisher: Future Science Ltd
Citation Info: Pearson RM, Sunoqrot S, Hsu HJ, Bae JW, Hong S. Dendritic nanoparticles: the next generation of nanocarriers? Therapeutic Delivery. 2012 Aug;3(8):941-59. 10.4155/TDE.12.76
Type: Article
Description: According to the guidelines provided by the publisher, this article is the pre-reviewed submitted manuscript to Therapeutic Delivery and does not incorporate adjustments to the content after peer reviewing. The citation for the published work is: R. M. Pearson, S. Sunoqrot, H.-j. Hsu, J. W. Bae, S. Hong, Therapeutic Delivery 3, 941 (2012).
URI: http://hdl.handle.net/10027/11306
ISSN: 2041-5990
Sponsor: This work has been supported by National Science Foundation under grant # CBET-0931472, Susan G Komen Foundation under grant # KG100713, and University of Illinois Foundation. RM Pearson was partially supported by a graduate fellowship from the American Foundation for Pharmaceutical Education.
Date Available in INDIGO: 2014-03-13
 

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