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Enamel-Related Gene Products in Calvarial Development

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Title: Enamel-Related Gene Products in Calvarial Development
Author(s): Atsawasuwan, Phimon; Lu, Xuanyu; Ito, Yoshihiro; Chen, Yinghua; Gopinathan, Gokul; Evans, Carla A.; Kulkarni, Ashok B.; Gibson, Carolyn W.; Luan, Xianghong; Diekwisch, Thomas G.H.
Subject(s): enamel amelogenin ameloblastin
Abstract: Enamel-related gene products (ERPs) are detected in non-enamel tissues such as bone. We hypothesized that if functional, ERP expression corresponds with distinct events during osteoblast differentiation and affects bone development and mineralization. In mouse calvariae and MC3T3 cells, expression profiles of enamel-related gene products (ERPs) correlated with key events in postnatal calvarial development and MC3T3 cell mineralization. Developing skulls from both Amel- and Ambn-deficient animals were approximately 15% shorter when compared to wild-type controls, and their sutures remained patent for a longer period of time. Analysis of Amel- and Ambn-deficient calvaria and calvarial osteoblast cultures revealed a dramatic reduction in mineralized nodules, a significant reduction in Runx2, Sp7, Ibsp, and Msx2 expression, and a reduction in Alx4 in Amel-deficient calvariae versus an increase in Alx4 in Ambn-deficient calvariae. Together, these data indicate that ERP expression follows defined developmental profiles and affects osteoblast differentiation, mineralization, and calvarial bone development. We propose that in parallel to their role in the developing enamel matrix, ERPs have retained an evolutionary conserved function related to the biomineralization of bones.
Issue Date: 2013-07
Publisher: Sage Publications
Citation Info: Atsawasuwan, P., Lu, X., Ito, Y., Chen, Y., Gopinathan, G., Evans, C. A., Kulkarni, A. B., Gibson, C. W., Luan, X. and Diekwisch, T. G. H. Expression and Function of Enamel-related Gene Products in Calvarial Development. Journal of Dental Research. 2013. 92(7): 622-628. DOI: 10.1177/0022034513487906
Type: Article
Description: This is a copy of an article published in the Journal of Dental Research © 2013 SAGE Publications.
URI: http://hdl.handle.net/10027/11164
ISSN: 0022-0345
Sponsor: This study was supported by NIDCR grants DE18057, DE19155 to XL, DE18900 to TGHD, and the Thomas M Graber AAOF fellowship to PA.
Date Available in INDIGO: 2014-07-23
 

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