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White-matter tract integrity in late-life depression: associations with severity and cognition

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Title: White-matter tract integrity in late-life depression: associations with severity and cognition
Author(s): Charlton, R. A.; Lamar, M.; Zhang, A.; Yang, S.; Ajilore, O.; Kumar, A.
Subject(s): Aging cognition depression
Abstract: BACKGROUND: Although significant changes in both gray and white matter have been noted in late-life depression (LLD), the pathophysiology of implicated white-matter tracts has not been fully described. In this study we examined the integrity of specific white-matter tracts in LLD versus healthy controls (HC). METHOD: Participants aged ≥60 years were recruited from the community. The sample included 23 clinically diagnosed individuals with LLD and 23 HC. White-matter integrity metrics [fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD)] were calculated in the bilateral cingulum and uncinate fasciculus. Depression severity was measured using the Center for Epidemiological Studies Depression Scale (CESD). Composite scores for learning and memory and executive function were created using standardized neuropsychological assessments. RESULTS: White-matter integrity was lower in LLD versus HC in the bilateral cingulum and right uncinate fasciculus (p⩽0.05). In the whole sample, depression severity correlated with integrity in the bilateral cingulum and right uncinate fasciculus (p ≤0.05). In patients, depression severity correlated with the integrity of the left uncinate fasciculus (p = 0.03); this tract also correlated with executive function (p = 0.02). Among HC, tract integrity did not correlate with depression scores; however, learning and memory correlated with integrity of the bilateral uncinate fasciculus and bilateral cingulum; executive function correlated with the right uncinate and left cingulum (p ≤0.05). CONCLUSIONS: White-matter tract integrity was lower in LLD than in HC and was associated with depression severity across all participants. Tract integrity was associated with cognition in both groups but more robustly among HC.
Issue Date: 2013-09
Publisher: Cambridge University Press
Citation Info: Charlton, R. A., Lamar, M., Zhang, A., Yang, S., Ajilore, O. and Kumar, A. White-matter tract integrity in late-life depression: associations with severity and cognition. Psychological Medicine. 2013. 1-11. doi 10.1017/s0033291713001980
Type: Article
Description: This is a copy of an article published in Psychological Medicine © 2013 Cambridge University Press. The final publication is available at http://journals.cambridge.org/action/displayJournal?jid=PSM
URI: http://hdl.handle.net/10027/11131
ISSN: 1469-8978
Sponsor: Funding for this study was provided by the National Institute of Mental Health (NIMH) 7RO1 MH073989-04 (A.K.).
Date Available in INDIGO: 2014-09-04
 

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