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Long-Term Inflammation and Glucocorticoid Therapy Impair Skeletal Modeling During Growth in Childhood Crohn Disease

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Title: Long-Term Inflammation and Glucocorticoid Therapy Impair Skeletal Modeling During Growth in Childhood Crohn Disease
Author(s): Tsampalieros, Anne; Lam, Carol K. L.; Spencer, Jenna C.; Thayu, Meena; Shults, Justine; Zemel, Babette S.; Herskovitz, Rita M.; Baldassano, Robert N.; Leonard, Mary B.
Subject(s): glucocorticoid bone disease bone growth Crohn's Disease
Abstract: Context: Glucocorticoids and inflammation inhibit bone formation; however, the impact on skeletal modeling is unknown. Objectives: The objectives of the study were to examine changes inbonemineral density(BMD) and cortical structure after Crohn disease (CD) diagnosis and identify associations with growth, glucocorticoids, and disease activity. Design/Participants: This was a prospective cohort study among 76 CD participants, aged 5-21 years. Tibia quantitative computed tomography trabecular BMD and cortical dimensions were obtained at diagnosis and 6 and 12 and a median of 42 months later; 51 completed the final visit. Outcomes: Sex, race, and age-specific Z-scores were generated for outcomes based on more than 650 reference participants, and cortical dimension Z-scores were further adjusted for tibia length. Generalized estimating equations were used to model changes in Z-scores. Results: Disease activity improved over the study interval (P <.001). TrabecularBMDZ-scoresimproved over the first 6 months; increases were associated with improved disease activity (P <.001), younger age (P <.005), and increases in vitamin D levels (P = .02). Greater increases in tibia length were associated with greater increases in cortical area Z-scores (P <.001). Greater glucocorticoid doses and disease activity were significantly associated with failure to accrue cortical area and were more pronounced with greater linear growth (interaction P <.05). Mean (+/- SD) trabecular BMD (similar to 1.0 +/- 1.21) and cortical area (similar to 0.57 +/- 1.10) Z-scores at the final visit were significantly reduced. Conclusions: CD was associated with persistent deficits in trabecular BMD, although younger participantsdemonstratedagreater potential for recovery. In addition, greater lineargrowthwasassociated with a greater recovery of cortical dimensions, especially among participants with less glucocorticoid exposure and inflammation. These data suggest that younger age and concurrent growth provide a window of opportunity for skeletal recovery.
Issue Date: 2013-08
Publisher: Endocrine Society
Citation Info: Tsampalieros, A., Lam, C. K. L., Spencer, J. C., Thayu, M., Shults, J., Zemel, B. S., Herskovitz, R. M., Baldassano, R. N. and Leonard, M. B. Long-Term Inflammation and Glucocorticoid Therapy Impair Skeletal Modeling During Growth in Childhood Crohn Disease. Journal of Clinical Endocrinology & Metabolism. 2013. 98(8): 3438-3445. DOI: 10.1210/jc.2013-1631
Type: Article
Description: This is a copy of an article published in the Journal of Clinical Endocrinology and Metabolism © 2013 Endocrine Society.
ISSN: 0021-972X
Date Available in INDIGO: 2014-08-10

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