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Transcriptional regulation of endothelial cell and vascular development

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Title: Transcriptional regulation of endothelial cell and vascular development
Author(s): Park, Changwon; Kim, Tae Min; Malik, Asrar B.
Subject(s): endothelial cells vasculogenesis angiogenesis reprogramming
Abstract: The establishment and maintenance of the vascular system is critical for embryonic development and postnatal life. Defects in endothelial cell development and vessel formation and function lead to embryonic lethality and are important in the etiology of vascular diseases. Here we review the underlying molecular mechanisms of endothelial cell differentiation, plasticity, and the development of the vasculature. This review focuses on the interplay among transcription factors and signaling molecules that specify the differentiation of vascular endothelial cells. We also discuss recent progress on reprogramming of somatic cells towards distinct endothelial cell lineages and its promise in regenerative vascular medicine.
Issue Date: 2013-05
Publisher: American Heart Association
Citation Info: Park C, Kim TM, Malik AB. Transcriptional regulation of endothelial cell and vascular development.Circulation Research. 2013 May 10;112(10):1380-400. doi: 10.1161/CIRCRESAHA.113.301078.
Type: Article
Description: This is a copy of an article published in the Circulation Research © 2013 American Heart Association. The final publication is available at http://circres.ahajournals.org/doi: 10.1161/CIRCRESAHA.113.301078
URI: http://hdl.handle.net/10027/10984
ISSN: 1524-4571
Sponsor: This work was supported by the March of Dimes Foundation, 5-FY12-44 (to CP), the American Heart Association, 11SDG7390074 (to CP) and NIH R01 HL45638 (to ABM), NIH R01 HL90152 (to ABM), NIH P01 60678 (to ABM), and NIH P01 77806 (to ABM).
Date Available in INDIGO: 2014-01-03
 

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