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Mutations in components of antiviral or microbial defense as a basis for breast cancer

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Title: Mutations in components of antiviral or microbial defense as a basis for breast cancer
Author(s): Friedenson, Bernard
Subject(s): Breast cancer infection breast cancer immunity breast cancer virus
Abstract: In-depth functional analyses of thousands of breast cancer gene mutations reveals vastly different sets of mutated genes in each of 21 different breast cancer genomes. Despite differences in which genes are mutated, innate immunity pathways and metabolic reactions supporting them are always damaged. These functions depend on many different genes. Mutations may be rare individually but each set of mutations affects some aspect of pathogen recognition and defense, especially those involving viruses. Some mutations cause a dysregulated immune response, which can also increase cancer risks. The frequency of an individual mutation may be less important than its effect on function. This work demonstrates that acquired immune deficiencies and dysregulation in cancer can occur because of mutations. Abnormal immune responses represent a hidden variable in breast cancer - viral association studies. Compensating for these abnormalities may open many new opportunities for cancer prevention and therapy.
Issue Date: 2013-11
Publisher: Springer Verlag
Citation Info: Friedenson B. Mutations in components of antiviral or microbial defense as a basis for breast cancer.Functional and Integrative Genomics. 2013 Nov;13(4):411-24. doi: 10.1007/s10142-013-0336-1.
Type: Article
Description: Post print version of article may differ from published version. The final publication is available at springerlink.com; DOI:10.1007/s10142-013-0336-1
URI: http://hdl.handle.net/10027/10983
ISSN: 1438-7948
Date Available in INDIGO: 2014-01-03
 

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