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Microperimetric Sensitivity in Patients on Hydroxychloroquine (Plaquenil) Therapy

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Title: Microperimetric Sensitivity in Patients on Hydroxychloroquine (Plaquenil) Therapy
Author(s): Jivrajka, Renu V.; Genead, Mohamed A.; McAnany, J. Jason; Chow, Clement C.; Mieler, William F.
Subject(s): microperimetry retinopathy screening plaquenil therapy
Abstract: Purpose: The purpose of this study was to measure macular sensitivity using microperimetry in patients on Plaquenil therapy without evidence of retinopathy as assessed by recommended screening standards.Methods: Sixteen patients from a clinical practice treated with 200 or 400 mg/day of Plaquenil for more than 5 years, without visual complaints (visual acuity 20/25 or better), and without a history of diabetes or macular disease were included. Participants underwent a complete ophthalmic examination with spectral-domain optical coherence tomography (SD-OCT), 10-2 Humphrey visual field (HVF), fundus autofluoresecene (FAF), multifocal electroretinography (mfERG), and microperimetry that covered the central 12° of the visual field. Ten age-similar, visually normal subjects served as controls.Results: The average age of the study cohort was of 54.5 years, with an average daily Plaquenil dose of 4.00 mg/kg/day (range, 1.77-6.67 mg/kg/day) and an average cumulative dose of 1485 g (range, 256-3650 g). All patients had normal ocular exams, and no evidence of retinopathy based on 10-2 HVF, FAF, mfERG, and SD-OCT. The mean retinal sensitivity by microperimetry was 15.0 dB (OD) and 14.6 dB (OS). The overall mean microperimetry sensitivity of the patients (14.7±1.9 dB) was significantly lower (P<0.001) than that of the controls (16.5±2.1 dB).Conclusions: Patients on Plaquenil without clinical evidence of retinal toxicity can have reduced retinal sensitivity, as assessed by microperimetry. The mean sensitivity difference between the patients and controls suggests that microperimetry can provide important information regarding visual function in patients on Plaquenil therapy.
Issue Date: 2013-09
Publisher: Nature Publishing Group
Citation Info: Jivrajka RV, Genead MA, McAnany JJ, Chow CC, Mieler WF. Microperimetric sensitivity in patients on hydroxychloroquine (Plaquenil) therapy. Eye (Lond). 2013 Sep;27(9):1044-52. doi: 10.1038/eye.2013.112.
Type: Article
Description: This is a copy of an article published in Eye © 2013 Nature Publishing Group
ISSN: 1476-5454
Sponsor: Funds from the Foundation Fighting Blindness, Columbia, Maryland; Pangere Corporation, Gary, Indiana; Grant Healthcare Foundation, Lake Forest, Illinois; NIH core grant EY01792; NIH research grant R00EY019510 (JM). Illinois Society for Prevention of Blindness
Date Available in INDIGO: 2014-04-15

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