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Topical Dorzolamide for Treatment of Cystoid Macular Edema in Patients with Choroideremia

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Title: Topical Dorzolamide for Treatment of Cystoid Macular Edema in Patients with Choroideremia
Author(s): Genead, Mohamed A.; McAnany, J. Jason; Fishman, Gerald A.
Subject(s): Cystoid macular edema Choroideremia Carbonic anhydrase inhibitor Spectraldomain OCT
Abstract: PURPOSE: To determine the value of a topical carbonic anhydrase inhibitor on the macular thickness and function in choroideremia patients with cystoid macular edema. METHODS: : Two choroideremia patients with cystoid macular edema, observed by spectral-domain optical coherence tomography, were treated with a topical form of carbonic anhydrase inhibitor. Examinations performed before and during treatment included best-corrected visual acuity by using the Early Treatment Diabetic Retinopathy Study charts and contrast sensitivity measured with briefly presented grating targets and the Pelli-Robson letter contrast sensitivity chart, microperimetry, and spectral-domain optical coherence tomography. RESULTS: : The 2 choroideremia patients treated with dorzolamide 2% formulation had a noticeable reduction in macular thickness by spectral-domain optical coherence tomography. This reduction was found in both eyes after 2 months of treatment. After an additional 3 months of the same treatment regimen, a more noticeable reduction in macular thickness was observed. The two study patients had improvement of their visual acuity, in at least one eye, on Early Treatment Diabetic Retinopathy Study charts, but no clinically significant changes for the other measures of visual function. CONCLUSION: : The present study shows the potential efficacy of topical dorzolamide for treating choroideremia patients with cystoid macular edema.
Issue Date: 2012-04
Publisher: Lippincott, Williams & Wilkins
Citation Info: Genead MA, McAnany JJ, Fishman GA. Topical dorzolamide for treatment of cystoid macular edema in patients with choroideremia. Retina. 2012 Apr;32(4):826-33. doi: 10.1097/IAE.0b013e3182215ae9
Type: Article
Description: Post print version of article may differ from published version. The final publication is available at www.lww.com/; DOI:10.1097/IAE.0b013e3182215ae9
URI: http://hdl.handle.net/10027/10548
ISSN: 1539-2864
Sponsor: Supported by funds from the Foundation Fighting Blindness, Owings Mills, Maryland; Grant Healthcare Foundation, Lake Forest, Illinois; NIH research grant EY019510 (JM); NIH core grant EYO1792; and an unrestricted departmental grant from Research to Prevent Blindness
Date Available in INDIGO: 2013-11-19
 

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