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Evaluation of Retinal Nerve Fiber Layer Thickness in Retinitis Pigmentosa Patients Using Spectral-Domain OCT

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Title: Evaluation of Retinal Nerve Fiber Layer Thickness in Retinitis Pigmentosa Patients Using Spectral-Domain OCT
Author(s): Anastasakis, Anastasios; Genead, Mohamed A.; McAnany, J. Jason; Fishman, Gerald A.
Subject(s): retinitis pigmentosa spectral-domain OCT peripapillary retinal nerve fiber layer thickness measurements retinal nerve fiber layer abnormalities
Abstract: PURPOSE: To measure the peripapillary retinal nerve fiber layer (RNFL) thickness using spectral-domain optical coherence tomography in patients with retinitis pigmentosa. METHODS: Fifty eyes of 30 patients with retinitis pigmentosa underwent a complete ocular examination, including best-corrected visual acuity using a Snellen chart, slit-lamp biomicroscopic examination, and Goldmann applanation intraocular pressure measurement. Dilated fundus examination was performed using both direct and indirect ophthalmoscopy. In addition, all patients underwent peripapillary RNFL thickness measurements using an OPKO spectral-domain optical coherence tomography (OPKO Instrumentations, Miami, FL). RESULTS: The mean (± SD) age of the study cohort was 45.8 (± 16.3) years. Of the 50 eyes, 18 (36%) showed a thinning of the peripapillary RNFL in 1 or more quadrants and 21 (42%) showed a thickening of the peripapillary RNFL in 1 or more quadrants. Four eyes (8%) showed both thinning and thickening of the peripapillary RNFL thickness. The overall circumferential RNFL thickness of the 14 eyes that showed only thinning in at least 1 quadrant was 78.78 μm. For the 17 eyes that showed only thickening in at least 1 quadrant, the RNFL thickness was 119.69 μm. The values of the eyes with thinning and the eyes with thickening were significantly different from normal (t = 6.31 and P < 0.01 for thickening; t = 3.62 and P < 0.01 for thinning). CONCLUSION: Using spectral-domain optical coherence tomography testing, we demonstrated in the current study that the peripapillary RNFL thickness in patients with RP can be decreased, increased, or maintained within normal limits. Assessment of the RNFL thickness seems prudent in these patients, particularly for identifying notable degrees of RNFL thinning in those being considered for future therapeutic trials.
Issue Date: 2012-02
Publisher: Lippincott, Williams & Wilkins
Citation Info: Anastasakis A, Genead MA, McAnany JJ, Fishman GA. Evaluation of retinal nerve fiber layer thickness in patients with retinitis pigmentosa using spectral-domain optical coherence tomography. Retina. 2012 Feb;32(2):358-63. doi: 10.1097/IAE.0b013e31821a891a
Type: Article
Description: Post print version of article may differ from published version. The final publication is available at; DOI:10.1097/IAE.0b013e31821a891a
ISSN: 1539-2864
Sponsor: Foundation Fighting Blindness, Owing Mills, Maryland, and Grant Healthcare Foundation, Chicago, Illinois (GAF); NIH core grant EY01792; NIH research grant EY019510 (JJM) and an unrestricted departmental grant from Research to Prevent Blindness
Date Available in INDIGO: 2013-11-15

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