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Modulation of C1-Inhibitor and Plasma Kallikrein Activities by Type IV Collagen

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Title: Modulation of C1-Inhibitor and Plasma Kallikrein Activities by Type IV Collagen
Author(s): Ravindran, Sriram; Schapira, Marc; Patston, Philip A.
Subject(s): affect article Biomaterial Chicago Coagulation Collagen Illinois INHIBITION Medicine MODULATION oral Plasma Science SYSTEM Universities
Abstract: The contact system of coagulation can be activated when in contact with biomaterials. As collagen is being tested in novel biomaterials in this study, we have investigated how type IV collagen affects plasma kallikrein and C1-inhibitor. Firstly, we showed C1-inhibitor binds to type IV collagen with a Kd of 0.86 muM. The effects of type IV collagen on plasma kallikrein, factor XIIa, and beta-factor XIIa activity and on C1-inhibitor function were determined. Factor XIIa rapidly lost activity in the presence of type IV collagen, whereas plasma kallikrein and beta-factor XIIa were more stable. The rate of inhibition of plasma kallikrein by C1-inhibitor was decreased by type IV collagen in a dose-dependent manner. These studies could be relevant to the properties of biomaterials, which contain collagen, and should be considered in the testing for biocompatibility
Issue Date: 2012
Publisher: Hindawi Publishing Corporation
Citation Info: Ravindran, S., M. Schapira, et al. (2012). "Modulation of C1-Inhibitor and Plasma Kallikrein Activities by Type IV Collagen." Int.J.Biomater. 2012: 212417. DOI: 10.1155/2012/212417
Type: Article
Description: Copyright © 2012 Sriram Ravindran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
ISSN: 1687-8787
Sponsor: This work was supported by the National Institutes of Health Grant HL-49242 (to PAP) and by the Swiss National Science Foundation Grant 31-36080.92 (to M. Schapira).
Date Available in INDIGO: 2013-11-01

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