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An ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical development

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Title: An ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical development
Author(s): Soejarto, D.D.; Gyllenhaal, C.; Kadushin, M.R.; Southavong, B.; Sydara, K.; Bouamanivong, S.; Xaiveu, M.; Zhang, H.-J.; Franzblau, S.G.; Tan, Ghee T.; Pezzuto, J.M.; Riley, M.C.; Elkington, B.G.; Waller, D.P.
Subject(s): Laos biodiversity ethnobotanical survey interview methods medicinal plants bioactive compounds cancer HIV/AIDS tuberculosis malaria
Abstract: Context: An ethnobotany-based approach in the selection of raw plant materials to study was implemented. Objective: To acquire raw plant materials using ethnobotanical field interviews as starting point to discover new bioactive compounds from medicinal plants of the Lao People’s Democratic Republic. Methods: Using semi-structured field interviews with healers in the Lao PDR, plant samples were collected, extracted, and bio-assayed to detect bioactivity against cancer, HIV/AIDS, TB, malaria. Plant species demonstrating activity were recollected and the extracts subjected to a bioassay-guided isolation protocol to isolate and identify the active compounds. Results: Field interviews with 118 healers in 15 of 17 provinces of Lao PDR yielded 753 collections [573 species] with 955 plant samples. Of these 955, 50 extracts demonstrated activity in the anticancer, 10 in the anti-HIV, 30 in the anti-TB, and 52 in the anti-malarial assay. Recollection of actives followed by bioassay-guided isolation processes yielded a series of new and known in vitro-active anticancer and antimalarial compounds from 5 species. Discussion: Laos has a rich biodiversity, harboring an estimated 8,000-11,000 species of plants. In a country highly dependent on traditional medicine for its primary health care, this rich plant diversity serves as a major source of their medication. Conclusion: Ethnobotanical survey has demonstrated the richness of plant-based traditional medicine of Lao PDR, taxonomically and therapeutically. Biological assays of extracts of half of the 955 samples followed by in-depth studies of a number of actives have yielded a series of new bioactive compounds against the diseases of cancer and malaria.
Issue Date: 2012-01
Publisher: Informa Healthcare
Citation Info: Soejarto, D. D., Gyllenhaal, C., Kadushin, M. R., Southavong, B., Sydara, K., Bouamanivong, S., Xaiveu, M., Zhang, H. J., Franzblau, S. G., Tan, G. T., Pezzuto, J. M., Riley, M. C., Elkington, B. G., & Waller, D. P. 2012. An ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical development. Pharmaceutical Biology, 50(1): 42-60. DOI: 10.3109/13880209.2011.619700
Type: Article
Description: Post print version of article may differ from published version. The definitive version is available through Informa Healthcare at DOI: 10.3109/13880209.2011.619700
URI: http://hdl.handle.net/10027/10099
ISSN: 1388-0209
Sponsor: This research was supported by NIH Grants 1-UO1-TW-001015-1 and 2-UO1-TW001015-06, International Cooperative Biodiversity Groups (ICBG), through funds from the National Institutes of Health, National Science Foundation, and the US Department of Agriculture Foreign Agricultural Service.
Date Available in INDIGO: 2013-12-06
 

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